The 2025 Mercedes-Benz E-Class E 450 4MATIC is a midsize luxury sedan featuring a 3.0-liter turbocharged inline-six with mild hybrid assistance, delivering 375 horsepower and 369 lb-ft of torque. The all-new interior showcases Mercedes' Superscreen option with three displays spanning the entire dashboard, along with the latest MBUX infotainment and augmented reality navigation. Combining sophisticated ride quality, advanced driver assistance systems, and timeless elegance, the E 450 continues the E-Class legacy as the heart of the Mercedes lineup.